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I'm just so tired of being tired. My pill has a "divit" like a divider already so it cut very easily. (yes, youre fine) 2 level 1 lxjuice · 3 yr. Julia Cook Former RN, CCRN, CNRN- critical care and neuro certified at Intensive Care Units (1996–2004) Author has 143 answers and 47. I would wait until you can get them in 25mgs, then you can wean off by cutting up the 25mg Unless the tablet is scored for easy splitting you just shouldn't do it because you have no idea how much or how little of the drug may be in each half. My question, also, was should I take my regular 25 mg that night. Votes: +1 , dosage, sleep disorder Further information Seroquel uses and safety info. It should have a little place on the pill where to cut it. Com You've been taking it quite a while and if you get them, quetiapine withdrawals are no joke. 5 mg at lunch or to its safety or lack there of. I was on 50mg but at my last refill after casually mentioning that I'm too drowsy on it he told me straight up to try half, 25mg. As long it is not extended release I do not see a problem, never cut/split an ER Seroquel or for that matter any ER medication. Michael Katz Staff Optometrist at Temple University Hospital (2016–present) Author has 102 answers and 162. I didn't even know that was an option or that I could do that. Yes, my pill can be split in half. I have been on Seroquel for the past 10 years an I split them in half, I must add they are instant release. You will not read this anywhere but sometimes you have to make due with what you have. I don't have a pill spliter, so I am wondering if I can use a knife to cut it. If you want to be absolutely sure you can always ask your pharmacist. Is it okay to cut Seroquel (not XR) in half? I already cut it actually and it split right in half. Careful, cutting them on half can result in an explosion large enough to kill a small whale. It is even OK to cut the XR in half but it won’t be extended release any more. Scored tablets are manufactured so that equal amounts of the active ingredient are delivered and unscored tablets are not Yes its ok to cut seroquel / quetiapine in half as long as it is not the extended release variant XR. There was no mention of the effects of cutting up an taking my 12. I felt like you didn't really read my question, or explain the scientific reasons why it was ok to take 12.